This article is based on previous research

2019-08-26

This article is based on previous research work [43] in the field of distributed development of information systems [34]. In that work, the system infrastructure focusing on the three-level data model used in the different layers of our architecture is described.

Given the important regulatory roles Ub

2019-08-24

Given the important regulatory roles Ub signaling pathways play in eukaryotes, bacterial pathogens and viruses have evolved elaborate mechanisms to hijack host Ub signaling pathways and evade the immune response.

To simulate the inhibition of the enzyme by

2019-08-23

To simulate the inhibition of the enzyme by organophosphorus, carbamate insecticides or nerve agents, a reversible cholinesterase inhibitor physostigmine was used for most experiments for safety reasons. However, the results of the measurements were verified using the soman organophosphate, which is one of the strongest known inhibitors and therefore has an extraordinary military significance.

Introduction Cell transplantation therapies

2019-08-22

Introduction Cell transplantation therapies using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC)-derived retinal tissue (ESC/iPSC retina) or TL32711 have emerged as therapeutic options for retinal degeneration following recent breakthroughs.

In mammals neutrophil elastase is a

2019-08-21

In mammals, neutrophil elastase is a trypsin-like serine protease stored in the azurophilic granules of naïve neutrophils [15], [16].

Because aspirin and ibuprofen are NSAIDs

2019-08-20

Because aspirin and ibuprofen are NSAIDs, both cause a variety of adverse effects, including stomach ulcers, stomach bleeding, coagulation disorders, Enfuvirtide and cerebral microbleeds [13].

Natural and synthetic glucocorticoids perform their

2019-08-19

Natural and synthetic glucocorticoids perform their biological action in the organism through receptor-dependent mechanisms (e.g., by binding to the glucocorticoid receptors).

Altogether these data suggested that

2019-08-17

Altogether these data suggested that GlmU might be involved in the M. smegmatis biofilm mediated defence mechanisms.

The structure of the HOIP RBR–LDD

2019-08-16

The structure of the HOIP RBR–LDD module bound to UbcH5~Ub reveals insights into an activated HOIP component [47].

Introduction Uncorrected obesity has been

2019-08-15

Introduction Uncorrected obesity has been a major health problem and the prevalence of obesity is fast rising reaching an epidemic proportion [[1], [2], [3]].

All of these experiments in GM matter injury

2019-08-14

All of these experiments in GM matter injury models have identified an array of signaling mechanisms that are potentially important. First, Kim et al. proposed that CK2 acts as a negative modulator of NADPH oxidase [55]. Then Blanquet et al.

The two most important biological machineries

2019-08-13

The two most important biological machineries controlling proteostasis, PQC, and degradation are autophagy and the ubiquitin-proteasome system (UPS).

Hello world!

2018-07-29