• The associations between genetic factors and

  2021-02-23

  

  The associations between genetic factors and socio-emotional functioning are complex and almost certainly not direct. They are mediated through a variety of developmental processes including individual differences in personality traits (Davis and Loxton, 2013, Saphire-Bernstein et al., 2011). For th

• With regards to what might represent a typical baseline

  2021-02-23

  

  With regards to what might represent a typical “baseline” ChE (or AChE) activity in Saccostrea sp., it AP26113 should be remembered that the observed enzyme responses were obtained in laboratory exposures, over a narrow experimental window (96h), with specimens collected over the course of a week, d

• The genetic asymmetries between parental genomes are also th

  2021-02-23

  

  The genetic asymmetries between parental genomes are also the subject of genetic conflict theory. This concept proposes that paternally inherited imprinted genes “extract” nutrients from the mother during gestation. By contrast, maternally inherited genes counteract the effect of paternal genes (Con

• In contrast T bet downregulated the expression of

  2021-02-23

  

  In contrast, T-bet downregulated the expression of Tfh functional molecules, CD40L, ICOS, and IL-21; accordingly, T-bet overexpression abrogated the helper function of IL-12-stimulated CD4+ T cells. Thus, T-bet seems more involved in the downregulation of the helper functions than in the differentia

• A structural explanation for how RBR

  2021-02-23

  

  A structural explanation for how RBR RING1s handle their bound E2~Ubs differently from canonical RINGs has not been readily apparent. Only a few residue positions are strongly conserved in RING and RING1 domains, most of which are zinc-coordinating Cys and histidine residues. A key position in canon

• WES and validation by Sanger

  2021-02-23

  

  WES and validation by Sanger sequencing in PNGS-252 revealed an apparent homozygous c.4C>G missense alteration (GenBank: NM_014176.3), resulting in the amino 99 0 substitution p.Gln2Glu (Figure 1A). This mutation must be very rare, because this is not listed in the NHLBI Exome Sequencing Project or

• br Hypothesis on DDR protective mode of action The documente

  2021-02-22

  

  Hypothesis on DDR1 protective mode of action The documented protective role of DDR1 is quite impressive, demonstrated using different preclinical models (immunologic [46,54,58], obstructive [45], and hypertensive [50]) with different intervention paradigms: genetic ablation [45,50,58,72], silenci

• Chemokines act as ligands for the chemokine receptors

  2021-02-22

  

  Chemokines act as ligands for the chemokine receptors, which possess 7-transmembran domain-type proteins functionally coupled to G proteins. Leukocytes express 19 chemokine receptors which control their influx and activation at the site of inflammation. Human neutrophils express both CXCR-1 and CXCR

• These contrasting results observed with intra

  2021-02-22

  

  These contrasting results observed with intra-BNST combined injections of NOC-9 and CP 376395 on freezing (in the novel arena) versus anxiety-related behavior (in the EPM) suggest that CRF neurotransmission within this forebrain limbic site could be mainly involved in the modulation of more subtle a

• br Experimental section br Results br Discussion In our prev

  2021-02-22

  

  Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised Rat HGF / Hepatocyte Growth Factor Protein did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the product

• br Diseases which have been treated with proteins linked

  2021-02-22

  

  Diseases which have been treated with proteins linked to HSA A number of therapeutic products conjugated to HSA have now been approved for clinical use (Table 2). For example, fatty TNF-alpha, recombinant murine protein receptor derivatives of human insulin bound to HSA have applications in the

• Water solubility experimental data of water hydrocarbon

  2021-02-22

  

  Water solubility experimental data of 24 water + hydrocarbon mixtures are used to find a general correlation for CPA model parameters. Finally, the model is benchmarked against three complex water solubility data set (Athabasca bitumen + water mixtures) from the literature [25], [26]. The model reli

• During the past decade it became increasingly

  2021-02-22

  

  During the past decade, it became increasingly clear that the affinity and efficacy of small agonists acting on the orthosteric binding site of a GPCR can be modulated by ligands that bind to a topographically distinct (allosteric) binding site on the same GPCR molecule 33, 39, 40, 41, 42. This allo

• ERR is present early in

  2021-02-22

  

  ERRβ is present early in the developing placenta in a subset of cftr in extra-embryonic ectoderm destined to make up the chorion.19, 20 ERRβ is likely essential for reproduction. ERRβ expression is essential for the maintenance of pluripotency and self-renewal potential in mouse embryonic stem cells

• An Emerging Role for the EphrinB EphB RASA Signaling Axis

  2021-02-22

  

  An Emerging Role for the EphrinB2-EphB4-RASA1 Signaling Axis in Human Congenital Cerebrovascular Disorders Normal vascular development includes de novo blood vessel formation from endothelial cells (ECs) (vasculogenesis) 1, 2, expansion of the network through vessel sprouting, splitting, and remode

14838 records 712/990 page Previous Next First page 上5页 711712713714715 下5页 Last page