• Specifically equity injections in a multinational affiliate

  2022-10-14

  

  Specifically, equity injections in a multinational affiliate X located in an ACE country can be passed on as lending to another group member Y located in a different country with a high corporate income tax rate. For the group member Y, the interest on the loans is tax deductible, and at the same ti

• br Funding This work was supported by

  2022-10-14

  

  Funding This work was supported by Arena Pharmaceuticals, Inc, San Diego, CA, USA. Introduction 5-hydroxytryptamine 1B (5-HT1B) receptors are widely distributed in the central nervous system (CNS); they have various modulatory functions in drug reinforcement, appetitive behaviors, stress, moo

• br Introduction Endothelial progenitor cells EPCs present a

  2022-10-13

  

  Introduction Endothelial progenitor cells (EPCs) present a class of blood cells with an ability to form new blood vessels relying on pre-existing vessels, which contribute to postnatal angiogenesis [1], [2]. A wide range of studies have demonstrated that EPCs play a critical role in angiogenesis

• Vascular interventional radiology VIR laboratories perform a

  2022-10-13

  

  Vascular interventional radiology (VIR) laboratories perform a myriad of procedures ranging from simple tunneled peripherally inserted central catheter lines to complex transjugular intrahepatic portosystemic shunt placements. Infections are a common complication in the VIR environment; thus, the pr

• e mycin receptor br Materials and methods br Results br Disc

  2022-10-13

  

  Materials and methods Results Discussion Prostate cancer is the most common cancer in men in the United States and the second leading cause of cancer death. Therapeutic interventions include mainly: radical prostatectomy or radiation therapy (RT), with or without androgen deprivation therap

• The complex role of the human intestinal microbiota is emerg

  2022-10-13

  

  The complex role of the human intestinal microbiota is emerging and its functions has been elucidated when considering energy metabolism, nutrient digestion, vitamin synthesis, epithelial defenses and immune responses [34]. The colon is responsible for salvage of energy and possibly nitrogen from ca

• hydroxydopamine OHDA is a selective catecholaminergic neurot

  2022-10-13

  

  6-hydroxydopamine (6-OHDA) is a selective catecholaminergic neurotoxin mainly used to generate lesions in the nigrostriatal pathway in rats (Ungerstedt, 1968). The most common use of 6-OHDA is via unilateral injection into the rat medial forebrain bundle (MFB). DA depletion, nigral DA cell loss, and

• The H autoreceptors distributed mainly

  2022-10-12

  

  The H3 autoreceptors distributed mainly in the CNS act as a negative feedback on histamine synthesis and release from histaminergic neurons. Histamine is involved in many physiological functions such as sleep-wake regulation, circadian and feeding rhythm, thermal regulation, locomotion, learning, co

• br Introduction Topological hedgehogs keep generating intere

  2022-10-12

  

  Introduction Topological hedgehogs keep generating interest in point-set topology as they are a rich source of counterexamples and applications (for a comprehensive survey on topological hedgehogs we refer to [1]; see also [9]). They may be described as a set of spines identified at a single poin

• Prolonged sGC oxidative inhibition occurs in many

  2022-10-12

  

  Prolonged sGC oxidative inhibition occurs in many diseases [46,[86], [87], [88]]. Keeping sGC membrane-bound and functional under conditions of high oxidative stress requires a mechanism for restoring oxidized sGC (Fe3+) heme iron to its reduced (Fe2+) state. Without this redox regulation, the sGC e

• There are five subfamilies of P

  2022-10-12

  

  There are five subfamilies of P-type ATPases (I-V), which transport metal ions or phospholipids across membranes (Palmgren and Nissen, 2011). Although our studies indicate that the P-type ATPase domain is important for function, how it contributes to cGMP production is currently unknown. The P-type

• Despite efforts over the past decade

  2022-10-12

  

  Despite efforts over the past decade to shed light on the endosomal maturation process and its underlying Rab conversion, the context in which all the involved protein components interact needs to be further elucidated. After defining single components and modules of the machinery important for endo

• br Acknowledgments br Introduction Myelin one of the fundame

  2022-10-12

  

  Acknowledgments Introduction Myelin, one of the fundamental adaptations of vertebrates, is a multilamellar structure deriving from the spiral wrapping around the HAT Inhibitor II of the plasma membrane of myelin forming glia, oligodendrocytes in the central nervous system and Schwann cells (SC

• With the administration of OM fatty

  2022-10-12

  

  With the administration of OM3 fatty acids, it has previously been shown that the activation of GPR120 is linked to the secretion and circulating levels of the adipokine adiponectin [123] promoting anti-inflammation (downregulation of NF-κB) and insulin sensitivity [124]. Interestingly, Nrf2 also de

• br Materials and methods br Results

  2022-10-12

  

  Materials and methods Results Discussion Previously, it is well known that methionine and choline deficient (MCDD) or choline-deficient, L-amino acid-defined (CDAA) models are widely accepted in NASH research. MCDD or CDAA dietary model has been mimic human NASH in rodents by sequentially p

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